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Neuroscience of ADHD

Neuroscience of ADHD | Healthy Gamer

Parts of the brain

Huberman Lab: Min 24

Neural circuits

Default mode network

[!When is the default mode network active?]- when you're just sitting there

in [[Neuroscience of Depression]]

[!Parts of the default node network]- parts that are normally synchronized (like a band) when one is active, the others light up too - dorsal (top) lateral (side) prefrontal cortex - posterior singular cortex - lateral parietal lobe

[!Default mode network behaviour in ADHD or sleep deprivation?]- they aren't synchronized when one lights up, the others don't light up

Task networks

  • trying to make you goal oriented

[!When do task networks light up?]- when you try to suppress impulses

  • not scratching that itch

[!Parts of task networks]- medial prefrontal cortex communicates to other parts of the brain to suppress impulses

How the Default Mode Network and the task networks interact

[!Default Mode Network vs Task Networks in ADHD?]- usually anticorrelated When one is on, the other is off

ADHD: they're more synced - band playing instruments in a way that isn't sounding right - with treatment: becomes anticorrelated


[!What dopamine does?]- neuromodulator: makes some circuits more active than others

musical conductor ensure that task networks and default mode network aren't on at the same time

[!Dopamine effects on attention] creates a heightened state of focus narrowed audio and visual attention pay attention and motivated to want things to outside of the body

Low dopamine hypothesis

[!What happens to neurons with low dopamine?]- some neurons will fire when they shouldn't violin starts playing when it shouldn't

ADHD: self medication: boosts dopamine ADHD children & stimulants => calm non ADHD children go hyper

[[Adult ADHD Treatment#Treating low dopamine]]

Eye blinking

regulate how much info goes into nervous system - how large the bins are

  • blinking resets your perception of time
    • movie: aaaaaaand cut
  • high dopamine
    • less blinking
      • long term canabis users blink less
    • people overestimate how long something lasted
  • low dopamine (or tired)
    • more blinking
    • people underestimate how long something lasted


Why they work for children - teaches children to learn what focus is like - neuroplasticity

Increases dopamine and norepenephrine

in a chemically enhanced state, the brain is more plastic

Pros for stimulant

  • can tell it's working right away
  • people get attached
    • lose effects right away when you stop

Stimulant cons

  • revs up the rest of the body
  • ⬆️ blood pressure
  • sleep problems
  • jittery
  • can be abused
    • sold

Non stimulant Cons

  • takes week to work


  • fear
  • negative emotions


Insula and Amygdala are smaller in ADHD - when it's bigger, it can be more inhibited

Nucleus accombus

  • strongy affected by amygdala and insula

Prefrontal cortex

Orbital frontal cortex

  • emotions + decision making

What makes

What stimulant meditations do?

  • strengthens the pre-frontal cortex

  • Impulse control

  • maturity

Executive function

  • ability to plan and execute tasks
  • example: cleaning your room
    • 4 year old
    • they can do the individual tasks
    • putting the books away
    • unable to "clean your room"
  • It doesn't matter how important things are, it's not intentional,


Last update: 2023-04-24